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B7-H1/PD-1 blockade therapy in urological malignancies: current status and future prospects

Abstract

The stimulatory and inhibitory coreceptors expressed by T lymphocytes are known to play critical roles in regulating cancer immunity. An array of inhibitory coreceptors involved in the inhibition of T-cell functions and the blockade of immune activation have been discovered in recent years, the most important of which are cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmmed death-1 (PD-1), and B7 homolog 1 (B7-H1). Immunotherapies targeting T-cell coinhibitory molecules have proved to be effective in cancer treatment. Several kinds of monoclonal antibodies have been tested in preclinical studies, with better outcomes than conventional therapies in many malignancies. Common urological malignancies including renal cell carcinoma, bladder cancer and prostate cancer are supposed to be immunogenic cancer types and not so sensitive to conventional therapies as other malignancies. This review will focus on B7-H1/PD-1 blockade therapy in urological malignancies, summarizing the results of clinical trials as well as the challenges and prospects of this emerging immunotherapy.

Tumori 2015; 101(5): 549 - 554

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000326

Authors

Lun Yu, Yonghua Wang, Shixiu Shao, Meng Yang, Haitao Niu, Qinchao Yu, Xinshen Wang

Article History

Disclosures

Financial support: This work was supported by the National Natural Science Foundation of China (No. 81101932).
Conflict of interest: The authors declare that they have no conflict of interests regarding the publication of this paper.

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Authors

Affiliations

  • Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao - China

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