Association of vitiligo and response in patients with metastatic malignant melanoma on temozolomide


Vitiligo-like lesions, although rare, are believed to be a prognostic factor in malignant melanoma. While a predictive role for such lesions was shown with immunomodulatory therapies, this relation was not demonstrated with temozolomide. We present 3 patients with metastatic malignant melanoma who developed vitiligo-like skin lesions accompanying good response to treatment and prolonged survival. Onset of vitiligo-like lesions with temozolomide in metastatic malignant melanoma may predict long-term response for this treatment.

Tumori 2015; 101(2): e67 - e69

Article Type: CASE REPORT



Ali Murat Tatli, Ali Ayberk Besen, Mehmet Emin Kalender, Mukremin Uysal, Deniz Aslan, Sema Sezgin Goksu, Seyda Gulenay Gunduz, Hasan Senol Coskun

Article History


Financial support: No financial support was received for this submission.
Conflict of interest: The authors have no conflict of interest.

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  • Department of Medical Oncology, Van Training and Research Hospital, Van - Turkey
  • Department of Medical Oncology, Gaziantep University Faculty of Medicine, Gaziantep - Turkey
  • Department of Medical Oncology, Afyon Kocatepe University Faculty of Medicine, Afyonkarahisar - Turkey
  • Department of Medical Oncology, Erzurum Training and Research Hospital, Erzurum - Turkey
  • Department of Medical Oncology, Kayseri Training and Research Hospital, Kayseri - Turkey
  • Department of Medical Oncology, Antalya Training and Research Hospital, Antalya - Turkey
  • Department of Medical Oncology, Antalya University Faculty of Medicine, Antalya - Turkey

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