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Assessment of chemokine serum levels in epithelial ovarian cancer patients

Abstract

Aims and background. The study was undertaken to investigate CCL2/MCP-1, CCL3/ MIP-1/, CCL4/MIP-1β, CCL5/RANTES and CXCL8/IL-8 women with epithelial ovarian cancer.
Methods and study design. Sixteen patients diagnosed with epithelial ovarian cancer and 18 healthy women with no evidence of malign neoplasia (control group) aged from 23 to 89 years (mean ± SEM, 58.7 ± 2.3) were included. The epithelial ovarian cancer patients underwent laparotomy and debulking surgery. Chemokines serum levels were measured by cytometric bead array. Statistical analysis was performed using Mann-Whitney and Kendall’s tau. P >0.05 was considered statistically significant for all analyses.
Results. The tumor staging (FIGO) was classified into: I in 4 cases (25%), III in 5 cases (31.3%) and stage IV in 7 cases (43.8%). Sera chemokine dosages of CCL2/MCP-1 and CCL4/MIP-1β were lower in epithelial ovarian cancer patients than in the control group (P = 0.021 and P = 0.030, respectively). No significant difference between groups was observed in the levels of CCL3/MIP-1α, CCL5/RANTES and CXCL8/IL-8. No association between the chemokines analyzed and tumor stage was found. The serum level of CCL4/MIP-1β was correlated with CA-125.
Conclusions. The study of serum levels of CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP- 1β, CCL5/RANTES and CXCL8/IL-8 chemokines in epithelial ovarian cancer patients identified a down-regulation in CCL2/MCP-1 and CCL4/MIP-1β, which suggests that the two chemokines may play an important role in the pathophysiology of ovarian cancer.

Tumori 2013; 99(4): 540 - 544

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1361.15108

Authors

João Oscar Almeida Falcão-Júnior, Andréa Teixeira-Carvalho, Eduardo Batista Cândido, Elisa Lopes Lages, Gustavo Ferreira Freitas G, Rívia Mara Lamaita, Lívia Paula Freire Bonfim, Rafael Borges Salera, Paulo Traiman P, Agnaldo Lopes da Silva-Filho

Article History

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Authors

  • Falcão-Júnior, João Oscar Almeida [PubMed] [Google Scholar]
    Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP, Brazil
  • Teixeira-Carvalho, Andréa [PubMed] [Google Scholar]
    Laboratory of Biomarkers and Monitoring Diagnosis, Rene Rachou Research Center, Oswaldo Cruz Foundation - Belo Horizonte, MG, Brazil
  • Cândido, Eduardo Batista [PubMed] [Google Scholar]
    Department of Obstetrics and Gynecology, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
  • Lages, Elisa Lopes [PubMed] [Google Scholar]
    Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP, Brazil
  • Freitas G, Gustavo Ferreira [PubMed] [Google Scholar]
    Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP, Brazil
  • Lamaita, Rívia Mara [PubMed] [Google Scholar]
    Pró-Cria Clinic of Assisted Reproduction, MaterDei Hospital, Belo Horizonte, MG, Brazil
  • Bonfim, Lívia Paula Freire [PubMed] [Google Scholar]
    Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP, Brazil
  • Salera, Rafael Borges [PubMed] [Google Scholar]
    Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP, Brazil
  • Traiman P, Paulo [PubMed] [Google Scholar]
    Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP, Brazil
  • da Silva-Filho, Agnaldo Lopes [PubMed] [Google Scholar]
    Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP, Brazil

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