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Acute immune hematological complication of oxaliplatin. A series of 3 cases

Abstract

We report a series of three cases of oxaliplatin-related hematological immune reactions. Two patients developed acute immune hemolytic anemia and the third patient had severe thrombocytopenia. One patient had minor undiagnosed hemolysis after the previous chemotherapy cycle and two of our three patients had minor allergic signs just before the hemolysis. Fifteen cases of immune hemolytic anemia have been reported in the literature, of which only the first was fatal. One case of hemolytic uremic syndrome has been described. Anemia in cancer patients is not always related to myelosuppression and hemolytic anemia can be a severe side effect of oxaliplatin administration.

Tumori 2014; 100(1): e17 - e19

Article Type: CASE REPORT

DOI:10.1700/1430.15831

Authors

Sylvain Garciaz, Sandrine Oziel-Taieb, Slimane Dermeche, Pauline Ries, Julie Vessaud, Jean-Luc Raoul

Article History

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Authors

  • Garciaz, Sylvain [PubMed] [Google Scholar]
    Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France
  • Oziel-Taieb, Sandrine [PubMed] [Google Scholar]
    Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France
  • Dermeche, Slimane [PubMed] [Google Scholar]
    Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France
  • Ries, Pauline [PubMed] [Google Scholar]
    Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France
  • Vessaud, Julie [PubMed] [Google Scholar]
    Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France
  • Raoul, Jean-Luc [PubMed] [Google Scholar]
    Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France

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