Advertisement

Review of the mechanisms involved in the abscopal effect and future directions with a focus on thymic carcinoma

Abstract

The abscopal effect is a rare phenomenon in radiotherapy, leading to impressive tumor regression outside the radiotherapy field. In this article we describe the occurrence of a postradiotherapy abscopal effect in an 89-year-old patient suffering from a metastatic neuroendocrine large-cell thymic carcinoma, the first case of the abscopal effect related to a thymic carcinoma reported in the literature. Along with the description of this case, we discuss and review the main potential mechanisms of bystander and abscopal effects in solid tumors so as to enable clinicians to identify and control these effects more resourcefully in the age of immunotherapy and stereotactic radiotherapy.

Tumori 2017; 103(3): 217 - 222

Article Type: REVIEW

DOI:10.5301/tj.5000616

Authors

Paul Lesueur, François Chevalier, Dinu Stefan, Jean-Louis Habrand, Delphine Lerouge, Radj Gervais

Article History

Disclosures

Informed consent: Consent from the patient’s wife has been obtained to report some anonymous personal data such as CT scans.
Financial support: None.
Conflict of interest: None.

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

Affiliations

  • Radiotherapy Unit, Centre François Baclesse, Caen - France
  • Laboratory for Research with Accelerated Heavy Ions, Institute of Cellular and Molecular Radiation Biology, CEA-GANIL, Caen - France
  • Medical Oncology Unit, Centre François Baclesse, Caen - France

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.