Role of functional imaging in treatment plan optimization of stereotactic body radiation therapy for liver cancer


We report the first known instance of the clinical use of 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) for the optimization of radiotherapy treatment planning and for the follow-up of acute toxicity in a patient undergoing stereotactic body radiation therapy for hepatocellular carcinoma. In our experience, HBS allowed the identification and the sparing of more functioning liver areas, thus potentially reducing the risk of radiation-induced liver toxicity.

Tumori 2016; 102(5): e21 - e24




Berardino De Bari, Raphael Jumeau, Letizia Deantonio, Salim Adib, Sarah Godin, Michele Zeverino, Raphael Moeckli, Jean Bourhis, John O. Prior, Mahmut Ozsahin

Article History


Financial support: None.
Conflict of interest: The authors have no conflicts of interest to disclose.

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  • Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland
  • Nuclear Medicine and Molecular Medicine Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland
  • Medical Physics, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland
  • Current address: Radiotherapy Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara - Italy
  • John O. Prior and Mahmut Ozsahin contributed equally as senior authors.

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