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A case of NUT midline carcinoma with no HPV infection, slight <i>EWSR1</i> rearrangement and strong expression of EGFR

Abstract

NUT midline carcinoma (NMC) is a rare neoplasm with a poor prognosis and involving mostly young patients. Here we describe a classic NMC with a BRD4-NUT fusion gene in a middle-aged woman. We also analyzed some biological features that could potentially influence its clinical behavior such as HPV infection, EWSR1 rearrangement, and the status of the EGFR gene.

Tumori 2013; 99(4): e152 - e155

Article Type: CASE REPORT

DOI:10.1700/1361.15114

Authors

Fausto Maffini, Christopher Alexander French, Michael James Cameron, Viviana Stufano, Massimo Barberis, Eleonora Pisa, Michela Manzotti, Augusto Cattaneo, Elvio De Fiori, Giuseppe Viale

Article History

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Authors

  • Maffini, Fausto [PubMed] [Google Scholar]
    Division of Pathology, European Institute of Oncology, Milan, Italy
  • French, Christopher Alexander [PubMed] [Google Scholar]
    Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  • Cameron, Michael James [PubMed] [Google Scholar]
    Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  • Stufano, Viviana [PubMed] [Google Scholar]
    Division of Pathology, European Institute of Oncology, Milan, Italy
  • Barberis, Massimo [PubMed] [Google Scholar]
    Division of Pathology, European Institute of Oncology, Milan, Italy
  • Pisa, Eleonora [PubMed] [Google Scholar]
    Division of Pathology, European Institute of Oncology, Milan, Italy
  • Manzotti, Michela [PubMed] [Google Scholar]
    Division of Pathology, European Institute of Oncology, Milan, Italy
  • Cattaneo, Augusto [PubMed] [Google Scholar]
    Division of Head and Neck Surgery, European Institute of Oncology, Milan; 5University of Milan School of Medicine, Milan, Italy
  • De Fiori, Elvio [PubMed] [Google Scholar]
    Division of Radiology, European Institute of Oncology, Milan, Italy
  • Viale, Giuseppe [PubMed] [Google Scholar]
    Division of Pathology, European Institute of Oncology, Milan, Italy

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