The prognostic impact of baseline C-reactive protein (CRP) in non-small-cell lung cancer (NSCLC) is debated. To evaluate this issue, we performed a systematic review and meta-analysis to explore the role of CRP value in predicting early-stage NSCLC survival.
Ten articles on early-stage NSCLC were eligible and included in our study. We performed a random-effects meta-analysis and assessed heterogeneity and publication bias. We pooled hazard ratio (HR) estimates and their 95% confidence intervals (CIs) on mortality for the comparison between the study-specific highest category of CRP level versus the lowest one.
In overall analysis, elevated pretreatment CRP values were significantly associated with poor overall survival (HR 1.60, 95% CI 1.30-1.97, p<0.001, I2 = 71.9%). Similar results were observed across considered strata. However, higher mortality risk was reported in studies in which CRP was combined with other factors (HR 1.96, 95% CI 1.58-2.45) and in those using a cutoff value of 3 mg/L (HR 1.89, 95% CI 1.52-2.35).
Based on our analysis, baseline high CRP level is significantly associated with poor prognosis in early-stage NSCLC. Further prospective controlled studies are needed to confirm these data.
Tumori 2016; 102(5): 441 - 449
Article Type: REVIEW
AuthorsGiovanni Leuzzi, Carlotta Galeone, Mara Gisabella, Leonardo Duranti, Francesca Taverna, Paola Suatoni, Daniele Morelli, Ugo Pastorino
- • Accepted on 09/06/2016
- • Available online on 11/06/2016
- • Published in print on 13/10/2016
This article is available as full text PDF.
- Leuzzi, Giovanni [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Galeone, Carlotta [PubMed] [Google Scholar] 2
- Gisabella, Mara [PubMed] [Google Scholar] 1
- Duranti, Leonardo [PubMed] [Google Scholar] 1
- Taverna, Francesca [PubMed] [Google Scholar] 3
- Suatoni, Paola [PubMed] [Google Scholar] 1
- Morelli, Daniele [PubMed] [Google Scholar] 4
- Pastorino, Ugo [PubMed] [Google Scholar] 1
Thoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan - Italy
Immunohematology and Transfusion Medicine Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy
Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy