Recurrent chromosomal abnormalities present in the leukemic cells of pediatric patients with acute lymphoblastic leukemia (ALL) often allow us to classify patients according to their prognosis, in order to establish further treatment. The dicentric translocation (9;12) consists of the rearrangement of the short arms of chromosomes 9 and 12 generating a dicentric chromosome (9;12). Patients with this alteration present a very good response to treatment and an excellent prognosis.
We present the case of an adolescent with ALL in which the dicentric translocation (9;12) was observed in the karyotype of the blasts at diagnosis.
Given the excellent results of our patient and most of the series published to date, an international study is necessary to determine the true prognostic significance of this molecular alteration.
Tumori 2017; 103(Suppl. 1): e44 - e46
Article Type: CASE REPORT
AuthorsLaura Illade, Victoria Fioravantti, Maitane Andion, Carmen Hernandez-Marques, Luis Madero, Alvaro Lassaletta
- • Accepted on 05/09/2017
- • Available online on 19/09/2017
- • Published online on 15/11/2017
This article is available as full text PDF.
- Illade, Laura [PubMed] [Google Scholar]
- Fioravantti, Victoria [PubMed] [Google Scholar]
- Andion, Maitane [PubMed] [Google Scholar]
- Hernandez-Marques, Carmen [PubMed] [Google Scholar]
- Madero, Luis [PubMed] [Google Scholar]
- Lassaletta, Alvaro [PubMed] [Google Scholar] , * Corresponding Author (email@example.com)
Pediatric Oncohematology Unit, Niño Jesús Hospital, Madrid - Spain