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Dicentric translocation (9;12) in acute lymphoblastic leukemia: a chromosomal abnormality with an excellent prognosis?

Abstract

Purpose

Recurrent chromosomal abnormalities present in the leukemic cells of pediatric patients with acute lymphoblastic leukemia (ALL) often allow us to classify patients according to their prognosis, in order to establish further treatment. The dicentric translocation (9;12) consists of the rearrangement of the short arms of chromosomes 9 and 12 generating a dicentric chromosome (9;12). Patients with this alteration present a very good response to treatment and an excellent prognosis.

Methods

We present the case of an adolescent with ALL in which the dicentric translocation (9;12) was observed in the karyotype of the blasts at diagnosis.

Results and conclusion

Given the excellent results of our patient and most of the series published to date, an international study is necessary to determine the true prognostic significance of this molecular alteration.

Tumori 2017; 103(Suppl. 1): e44 - e46

Article Type: CASE REPORT

DOI:10.5301/tj.5000683

Authors

Laura Illade, Victoria Fioravantti, Maitane Andion, Carmen Hernandez-Marques, Luis Madero, Alvaro Lassaletta

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • Pediatric Oncohematology Unit, Niño Jesús Hospital, Madrid - Spain

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