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Prostate volume index stratified prostate cancer risk in patients elected to a first random biopsy set

Abstract

Objective

To investigate prostate volume index (PVI), defined as the ratio of volume of the transitional zone on that of the peripheral zone, as a factor stratifying prostate cancer (PCA) risk in patients elected to a first random biopsy set.

Methods

The study evaluated 596 patients who were elected to a first random biopsy set because of suspected PCA in a period between September 2010 and September 2015. Prostate volume index was dichotomized to PVI ≤1 vs PVI >1. The multivariate logistic regression model investigated clinical factors with dichotomized PVI associating with PCA.

Results

The detection rate of PCA was 49%. The dichotomized PVI >1 stratified PCA risk (odds ratio [OR] 0.455; p<0.0001) beyond age (OR 1.062; p<0.0001), PSA (OR 1.167; p<0.0001), PV (OR 0.957; p<0.0001), and abnormal digital rectal examination (OR 2.094; p<0.0001). The goodness of fit statistics assessed model efficacy.

Conclusions

A large cohort of patients elected to a first random biopsy set had PCA risk stratified by dichotomized PVI beyond other clinical independent factors. Confirmatory studies are required.

Tumori 2017; 103(4): 374 - 379

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000607

Authors

Antonio B. Porcaro, Paolo Corsi, Nicolò de Luyk, Marco Sebben, Alessandro Tafuri, Leonardo Bizzotto, Giovanni Cacciamani, Davide De Marchi, Tania Processali, Daniele Mattevi, Giovanni Novella, Maria A. Cerruto, Matteo Brunelli, Salvatore Siracusano, Walter Artibani

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  •  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy
  •  Department of Pathology, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy

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