To evaluate the results of radiotherapy and the prognostic factors affecting local control in nonextremity Ewing sarcomas.
Between 1995 and 2011, 44 patients with nonextremity Ewing sarcomas were treated with radiotherapy. Tumor localizations were pelvis in 23, spine in 13, thoracic region in 5, and cranium in 3 patients. Tumor size was ≥8 cm in 56.8% of patients. Distant metastases were present in 19 of the patients at the time of diagnosis (43.1%). All patients were treated with 12 weeks of neoadjuvant chemotherapy followed by surgery and radiotherapy (45-54 Gy) or radiotherapy alone (54-64.8 Gy). Radiotherapy was applied due to microscopic residue (R1) in 5 patients after the operation and macroscopic tumor in 39 patients (macroscopic residue [R2] and nonresectable tumor).
Median follow-up was 49 months (range 9-195). Local failures developed in 7 patients (15.9%) and local control at 5 years was 81.4%. Local recurrence was detected in 6 patients (6/38) who did not have residual tumor after RT. Progression was detected in 1 patient (1/6) who had residual tumor. All those patients with local failure experienced further distant metastases. Possible prognostic factors such as age (≤17 vs >17), tumor localization, tumor volume (≤8 cm vs >8 cm), and M status at diagnosis (0 vs 1) were not related to local control.
Radiotherapy, either alone or adjuvant to surgery, provides local control in 80% of nonextremity Ewing sarcomas and plays an important role in treatment.
Tumori 2016; 102(2): 162 - 167
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsOzlem O. Akagunduz, Serra A. Kamer, Burcin Kececi, Bengu Demirag, Haldun Oniz, Mehmet Kantar, Nazan Cetingul, Dundar Sabah, Yavuz Anacak
- • Accepted on 28/01/2016
- • Available online on 19/02/2016
- • Published in print on 18/04/2016
This article is available as full text PDF.
- Akagunduz, Ozlem O. [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Kamer, Serra A. [PubMed] [Google Scholar] 1
- Kececi, Burcin [PubMed] [Google Scholar] 2
- Demirag, Bengu [PubMed] [Google Scholar] 3
- Oniz, Haldun [PubMed] [Google Scholar] 4
- Kantar, Mehmet [PubMed] [Google Scholar] 5
- Cetingul, Nazan [PubMed] [Google Scholar] 5
- Sabah, Dundar [PubMed] [Google Scholar] 2
- Anacak, Yavuz [PubMed] [Google Scholar] 1
Department of Radiation Oncology, Faculty of Medicine, Ege University, Izmir - Turkey
Department of Orthopedics and Traumatology, Faculty of Medicine, Ege University, Izmir - Turkey
Department of Pediatric Oncology, Dr. Behçet Uz Children’s Hospital, Izmir - Turkey
Department of Pediatric Oncology, Tepecik Training and Research Hospital, Izmir - Turkey
Department of Pediatric Oncology, Ege University Faculty of Medicine, Izmir - Turkey