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Advantage of sorafenib combined with radiofrequency ablation for treatment of hepatocellular carcinoma

Abstract

Background

Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Among the surgical and nonsurgical treatments available, radiofrequency ablation (RFA) and sorafenib have been shown to have efficacy. There is little evidence whether combination of these therapies would have additional benefits.

Methods

In a mouse model of HCC, effects of sorafenib were determined by tumor size, RFA-induced necrosis area (triphenyltetrazolium chloride staining), microvascular density (MVD; 4’,6-diamidino-2-phenylindole and anti-CD31 antibody staining), and tumor perfusion (magnetic resonance imaging).

Results

The RFA-induced necrosis area was 80.98 ± 9.14 and 69.49 ± 7.46 mm2 in mice administered 80 and 40 mg/kg sorafenib, respectively, but only 57.29 ± 3.39 mm2 in controls. Sorafenib also reduced tumor volume and enhanced RFA-induced tumor destruction in a dose-dependent manner, and reduced both MVD and tumor perfusion.

Conclusions

The results of our study suggest a potential role for combining RFA with sorafenib for treatment of HCC. Sorafenib could enhance RFA efficiency, possibly through its angiogenesis suppressive effects.

Tumori 2017; 103(3): 286 - 291

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000585

Authors

Zhe Tang, Muxing Kang, Bo Zhang, Jianke Chen, Heqing Fang, Qin Ye, Biao Jiang, Yulian Wu

Article History

Disclosures

Financial support: Supported by grants from the Natural Science Foundation of Zhejiang Province (No. LY15H160022) and the Traditional Chinese Medicine Foundation of Zhejiang Province (No. 2015ZA056).
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  •  Department of Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou - China
  •  Department of Ultrasound, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou - China
  •  Department of Pathology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou - China
  •  Department of Radiology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou - China
  • Zhe Tang and Muxing Kang authors contributed equally to this work.

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