Intracapsular carcinoma ex-pleomorphic adenoma of the parapharyngeal space: report of two cases and review of the literature



Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is an exceedingly rare entity.


The clinical records of two patients with primary carcinoma ex-pleomorphic adenoma of the parapharyngeal space surgically treated at two different centers were retrospectively analyzed.


Despite ultrasound-guided fine-needle aspiration cytology and magnetic resonance imaging, the correct diagnosis was preoperatively missed in both cases. Excision was obtained through a transcervical-transparotid approach in 1 case and a minimally-invasive endoscopic-assisted transcervical approach in the other. Definitive histology was consistent with intracapsular carcinoma ex-pleomorphic adenoma. Adjuvant radiotherapy was performed in the case with macroscopic malignant degeneration; both patients are alive and free from disease 36 months after surgery.


Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is a rare disease, and definitive diagnosis may be challenging. Surgery is the mainstay of treatment, but adjuvant radiotherapy also may be required in the presence of specific risk factors.

Tumori 2017; 103(Suppl. 1): e73 - e77

Article Type: CASE REPORT



Remo Accorona, Diego Barbieri, Davide Farina, Davide Lombardi, Mario Bussi, Piero Nicolai

Article History


Financial support: No grants or funding have been received for this study.
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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  • Unit of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Brescia - Italy
  • Departmente of Otorhinolaryngology, S. Raffaele “Vita e Salute” School of Medicine, Milan - Italy
  • Unit of Radiology, University of Brescia, Brescia - Italy

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