Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is an exceedingly rare entity.
The clinical records of two patients with primary carcinoma ex-pleomorphic adenoma of the parapharyngeal space surgically treated at two different centers were retrospectively analyzed.
Despite ultrasound-guided fine-needle aspiration cytology and magnetic resonance imaging, the correct diagnosis was preoperatively missed in both cases. Excision was obtained through a transcervical-transparotid approach in 1 case and a minimally-invasive endoscopic-assisted transcervical approach in the other. Definitive histology was consistent with intracapsular carcinoma ex-pleomorphic adenoma. Adjuvant radiotherapy was performed in the case with macroscopic malignant degeneration; both patients are alive and free from disease 36 months after surgery.
Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is a rare disease, and definitive diagnosis may be challenging. Surgery is the mainstay of treatment, but adjuvant radiotherapy also may be required in the presence of specific risk factors.
Tumori 2017; 103(Suppl. 1): e73 - e77
Article Type: CASE REPORT
AuthorsRemo Accorona, Diego Barbieri, Davide Farina, Davide Lombardi, Mario Bussi, Piero Nicolai
- • Accepted on 12/10/2017
- • Available online on 09/11/2017
- • Published online on 15/11/2017
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- Accorona, Remo [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Barbieri, Diego [PubMed] [Google Scholar] 2
- Farina, Davide [PubMed] [Google Scholar] 3
- Lombardi, Davide [PubMed] [Google Scholar] 1
- Bussi, Mario [PubMed] [Google Scholar] 2
- Nicolai, Piero [PubMed] [Google Scholar] 1
Unit of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Brescia - Italy
Departmente of Otorhinolaryngology, S. Raffaele “Vita e Salute” School of Medicine, Milan - Italy
Unit of Radiology, University of Brescia, Brescia - Italy