Before the wait-and-see policy became the standard approach in abdominal wall desmoid tumors, surgery was performed on a systematic basis. Surgery remains indicated for progressing tumors but its extent is debatable. The abdominal wall is a common site of origin of sporadic desmoids, usually associated with a favorable prognosis. We analyzed the results of surgery at this specific site.
Data from 33 patients affected by sporadic desmoid tumors of the abdominal wall (31 primary, 2 recurrent) consecutively treated at our cancer center between January 2000 and September 2013 were retrospectively studied.
Twenty-nine patients underwent surgery upfront and 1 after progression during the initial wait-and-see period. Prosthetic reconstruction of the abdominal wall was required in 28 patients. The average hospital stay was 5 days. Three patients developed surgical complications. Local recurrence-free survival was 90% at 5 and 10 years. Three patients had an uneventful childbirth during the follow-up after surgery.
Desmoid tumors of the abdominal wall have a favorable prognosis after surgical resection, which remains a safe and effective treatment. Wild-type tumors are common, whereas the incidence of S45F mutation in the beta-catenin gene is lower than in other anatomic sites. Upfront surgery may be considered in selected women who wish to bear a child.
Tumori 2016; 102(6): 582 - 587
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsChiara E. Mussi, Piergiuseppe Colombo, Chiara Lo Russo, Anaid Kasangian, Ferdinando Cananzi, Andrea Marrari, Emanuela Morenghi, Rita De Sanctis, Vittorio Quagliuolo
- • Accepted on 25/07/2016
- • Available online on 03/09/2016
- • Published in print on 01/12/2016
This article is available as full text PDF.
- Mussi, Chiara E. [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Colombo, Piergiuseppe [PubMed] [Google Scholar] 2
- Lo Russo, Chiara [PubMed] [Google Scholar] 2
- Kasangian, Anaid [PubMed] [Google Scholar] 1
- Cananzi, Ferdinando [PubMed] [Google Scholar] 1
- Marrari, Andrea [PubMed] [Google Scholar] 3
- Morenghi, Emanuela [PubMed] [Google Scholar] 4
- De Sanctis, Rita [PubMed] [Google Scholar] 3
- Quagliuolo, Vittorio [PubMed] [Google Scholar] 1
Department of Surgical Oncology, Humanitas Clinical and Research Center, Milan - Italy
Department of Pathology, Humanitas Clinical and Research Center, Milan - Italy
Department of Oncology, Humanitas Clinical and Research Center, Milan - Italy
Department of Statistics, Humanitas Clinical and Research Center, Milan - Italy