The use of helical tomotherapy (HT) for craniospinal irradiation (CSI) in pediatric patients remains an issue of discussion. In this study, we evaluated the integral dose (ID) to organs at risk (OARs) and to the whole body delivered with conventional 3-dimensional conformal radiotherapy (3D-CRT) and HT for pediatric patients and made a comparison according to different whole body volumes.
We selected 10 pediatric patients with different body volumes and of different ages undergoing CSI. Plans for 3D-CRT and HT were developed for each patient. The ID to OARs and to the whole body were compared and statistical analyses were performed to determine differences.
We noticed that variations of ID depend on the different anatomical location of the organs relatively to the target, with lower ID to OARs opposed to the target and increased ID to lateral organs: ID tomotherapy/3D-CRT ratio was higher in lungs, kidneys, and mammary region, while it was lower in heart, liver, thyroid, and esophagus. The ID of the body increased with large volumes both in HT and in 3D-CRT plans, but in tomotherapy plans ID increased significantly more with large volumes than with small ones.
While there are no differences in using tomotherapy or 3D-CRT with small body volumes, we found a difference with large volumes (≥20,000 mL vs ≤20,000 mL). Therefore, for very small patients, the use of intensity-modulated radiotherapy provided with tomotherapy to reduce the dose to OARs can be reconsidered.
Tumori 2016; 102(4): 387 - 392
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsSalvina Barra, Marco Gusinu, Giorgia Timon, Flavio Giannelli, Giulia Vidano, Maria Luisa Garrè, Renzo Corvò
- • Accepted on 22/02/2016
- • Available online on 07/04/2016
- • Published in print on 03/08/2016
This article is available as full text PDF.
- Barra, Salvina [PubMed] [Google Scholar] 1
- Gusinu, Marco [PubMed] [Google Scholar] 2
- Timon, Giorgia [PubMed] [Google Scholar] 3, * Corresponding Author (firstname.lastname@example.org)
- Giannelli, Flavio [PubMed] [Google Scholar] 1
- Vidano, Giulia [PubMed] [Google Scholar] 2
- Garrè, Maria Luisa [PubMed] [Google Scholar] 4
- Corvò, Renzo [PubMed] [Google Scholar] 1, 2, 3
Department of Radiation Oncology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genova - Italy
Department of Medical Physics, IRCCS Azienda Ospedaliera Universitaria San Martino- IST Istituto Nazionale per la Ricerca sul Cancro, Genova - Italy
School of Radiation Oncology, University of Genova, Genova - Italy
Department of Oncology, Istituto Giannina Gaslini, Genova - Italy