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Risk prediction model for disease-free survival in women with early-stage cervical cancers following postoperative (chemo)radiotherapy

Abstract

Purpose

To investigate disease-free survival (DFS) and prognostic factors following the administration of postoperative (chemo)radiotherapy in patients with early-stage cervical cancers.

Methods

The medical records of 1,069 patients from 10 participating institutions were reviewed. Statistically and clinically established factors were considered as candidates for constructing the prediction model. This model was validated, using bootstrapping to correct for optimistic bias.

Results

The 5-year DFS rate was 81.1%, with a median follow-up period of 59.6 months. The statistically significant prognostic factors were as follows: pelvic lymph node metastasis, histologic type, parametrial invasion, lymphovascular space invasion, and tumor size. The nomogram for DFS was constructed, and it demonstrated a good discrimination performance, with an internally validated concordance index of 0.72.

Conclusions

Our predictive model exhibited accurate predictions and may be useful in designing clinical trials to study if further chemotherapy can reduce the recurrence of disease in high-risk patients.

Post author correction

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000697

Authors

Hyoung Uk Je, Seungbong Han, Young Seok Kim, Joo-Hyun Nam, Won Park, Sanghyuk Song, Changhoon Song, Jin Hee Kim, Juree Kim, Won Sup Yoon, Mee Sun Yoon, Jin Hwa Choi, Joo-Young Kim

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • Department of Radiation Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan - South Korea
  • Department of Applied Statistics, Gachon University, Gyeonggi-do - South Korea
  • Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul - South Korea
  • Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul - South Korea
  • Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - South Korea
  • Department of Radiation Oncology, Kangwon National University Hospital, Gangwon-do - South Korea
  • Department of Radiation Oncology, Seoul National University Bundang Hospital, Gyeonggi-do - South Korea
  • Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu - South Korea
  • Departments of Radiation Oncology, Cheil General Hospital and Women’s Healthcare Center, Dankook University, College of Medicine, Seoul - South Korea
  • Department of Radiation Oncology, Korea University, Ansan Hospital, Gyeonggi-do - South Korea
  • Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Jeollanam-do - South Korea
  • Department of Radiation Oncology, Chung-Ang University Hospital, Seoul - South Korea
  • Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Gyeonggi-do - South Korea
  • Hyoung Uk Je and Seungbong Han contributed equally to this work and are considered co-first authors.

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