Single nucleotide polymorphisms (SNPs) in the DNA repair genes are believed to contribute to the clinical outcome of patients receiving platinum-based chemotherapy. We investigated the impact of 2 SNPs of excision repair cross-complementation group 1 and 2 of xeroderma pigmentosum complementation group G on the outcome in patients with non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy.
Between October 2007 and March 2012, we collected 374 blood samples from consecutive patients registered in the TAILOR trial. Four SNPs (rs11615, rs3212986, rs17655, rs1047768) were genotyped using real-time polymerase chain reaction.
The rs11615 polymorphism was associated with histotype (p = 0.0123). No other correlations were found with clinical variables or with
The findings suggest that the investigated SNPs do not make any significant contribution to the outcome of NSCLC.
Tumori 2016; 102(4): 367 - 375
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsEliana Rulli, Mirko Marabese, Sheila Piva, Lucia Bonomi, Elisa Caiola, Monica Ganzinelli
- • Accepted on 16/05/2016
- • Available online on 07/07/2016
- • Published in print on 03/08/2016
This article is available as full text PDF.
- Rulli, Eliana [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Marabese, Mirko [PubMed] [Google Scholar] 2
- Piva, Sheila [PubMed] [Google Scholar] 3
- Bonomi, Lucia [PubMed] [Google Scholar] 4
- Caiola, Elisa [PubMed] [Google Scholar] 2
- Ganzinelli, Monica [PubMed] [Google Scholar] 5
Clinical Research Methodology Laboratory, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy
Molecular Genetics Unit, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy
Oncology Department, Ospedale Fatebenefratelli e Oftalmico, Milan - Italy
Oncology Department, Ospedale Papa Giovanni XXIII, Bergamo - Italy
Thoracic Unit, Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy
Elisa Caiola and Monica Ganzinelli contributed equally to this work.